cingulum hippocampal Search Results


phcb mask [labeled "cingulum (hippocampus)]  (Johns Hopkins HealthCare)
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cingulum-hippocampus pathway  (Rocha labs)
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brain regions  (Holzel Diagnostika)
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Image Search Results


Comparing PHCB tissue microstructure between APOE -ε4 carriers and noncarriers. (A) Left: Deterministic tractography was conducted in each participant, and free water–corrected indices of bilateral PHCB microstructure (MD, FA) were extracted. Right: To examine associations with functional activity, these metrics were correlated with BOLD activity from an independently defined pDMN functional ROI during a perceptual discrimination task ( <xref ref-type=Shine et al., 2015 ). Example scene trials for the perceptual “odd-one-out” discrimination task are shown. (B) Plots comparing mean bilateral PHCB MD and FA for APOE -ε4 carriers and noncarriers. Individual data points are displayed jittered on each bar. (C) Scatter plots showing the association between scene (vs. “size” baseline) activity in the pDMN and MD (left) and FA (right) in the PHCB. A total of 25 data points are shown on each scatter plot (13 carriers, blue markers; 12 noncarriers, orange markers; see Section ). Abbreviations: BOLD, blood-oxygen level dependent; FA, fractional anisotropy; MD, mean diffusivity; PHCB, parahippocampal cingulum bundle; pDMN, posterior default mode network; ROI, region of interest. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.) " width="100%" height="100%">

Journal: Neurobiology of Aging

Article Title: Increased posterior default mode network activity and structural connectivity in young adult APOE- ε4 carriers: a multimodal imaging investigation

doi: 10.1016/j.neurobiolaging.2018.08.026

Figure Lengend Snippet: Comparing PHCB tissue microstructure between APOE -ε4 carriers and noncarriers. (A) Left: Deterministic tractography was conducted in each participant, and free water–corrected indices of bilateral PHCB microstructure (MD, FA) were extracted. Right: To examine associations with functional activity, these metrics were correlated with BOLD activity from an independently defined pDMN functional ROI during a perceptual discrimination task ( Shine et al., 2015 ). Example scene trials for the perceptual “odd-one-out” discrimination task are shown. (B) Plots comparing mean bilateral PHCB MD and FA for APOE -ε4 carriers and noncarriers. Individual data points are displayed jittered on each bar. (C) Scatter plots showing the association between scene (vs. “size” baseline) activity in the pDMN and MD (left) and FA (right) in the PHCB. A total of 25 data points are shown on each scatter plot (13 carriers, blue markers; 12 noncarriers, orange markers; see Section ). Abbreviations: BOLD, blood-oxygen level dependent; FA, fractional anisotropy; MD, mean diffusivity; PHCB, parahippocampal cingulum bundle; pDMN, posterior default mode network; ROI, region of interest. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: To restrict our analysis to the PHCB, we extracted the PHCB mask [labeled “cingulum (hippocampus)”] from the Johns Hopkins University ICBM-DTI-81 white-matter tractography atlas using FSLView (for similar approach, see ).

Techniques: Functional Assay, Activity Assay

Comparing parahippocampal cingulum bundle (PHCB) microstructure in APOE -ε4 carriers and noncarriers using TBSS. (A) A significant cluster (shown in green) was found showing greater FA in APOE -ε4 carriers versus noncarriers in the posterior PHCB ( p < 0.05, TFCE-corrected). (B) A subthreshold cluster (shown in red-yellow) reflecting lower MD in APOE -ε4 carriers versus noncarriers was identified in the posterior PHCB ( p < 0.005, uncorrected). For visualization purposes, clusters have been “thickened” using “TBSS fill” in FSL. There were no voxelwise differences for MD that survived stringent correction. Abbreviations: FA, fractional anisotropy; MD, mean diffusivity; PHCB, parahippocampal cingulum bundle; TBSS, tract-based spatial statistics. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Journal: Neurobiology of Aging

Article Title: Increased posterior default mode network activity and structural connectivity in young adult APOE- ε4 carriers: a multimodal imaging investigation

doi: 10.1016/j.neurobiolaging.2018.08.026

Figure Lengend Snippet: Comparing parahippocampal cingulum bundle (PHCB) microstructure in APOE -ε4 carriers and noncarriers using TBSS. (A) A significant cluster (shown in green) was found showing greater FA in APOE -ε4 carriers versus noncarriers in the posterior PHCB ( p < 0.05, TFCE-corrected). (B) A subthreshold cluster (shown in red-yellow) reflecting lower MD in APOE -ε4 carriers versus noncarriers was identified in the posterior PHCB ( p < 0.005, uncorrected). For visualization purposes, clusters have been “thickened” using “TBSS fill” in FSL. There were no voxelwise differences for MD that survived stringent correction. Abbreviations: FA, fractional anisotropy; MD, mean diffusivity; PHCB, parahippocampal cingulum bundle; TBSS, tract-based spatial statistics. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: To restrict our analysis to the PHCB, we extracted the PHCB mask [labeled “cingulum (hippocampus)”] from the Johns Hopkins University ICBM-DTI-81 white-matter tractography atlas using FSLView (for similar approach, see ).

Techniques:

Correlations between scene activity in the medial temporal lobe and parahippocampal cingulum bundle (PHCB) microstructure. Scatter plots showing the association between PHCB mean diffusivity and scene (vs. “size” baseline) activity in the (A) posterior parahippocampal gyrus (PHG, green markers) and (B) hippocampus (blue markers). A total of 25 data points are shown on each scatter plot (13 carriers, dark markers; 12 noncarriers, light markers; see Section ).

Journal: Neurobiology of Aging

Article Title: Increased posterior default mode network activity and structural connectivity in young adult APOE- ε4 carriers: a multimodal imaging investigation

doi: 10.1016/j.neurobiolaging.2018.08.026

Figure Lengend Snippet: Correlations between scene activity in the medial temporal lobe and parahippocampal cingulum bundle (PHCB) microstructure. Scatter plots showing the association between PHCB mean diffusivity and scene (vs. “size” baseline) activity in the (A) posterior parahippocampal gyrus (PHG, green markers) and (B) hippocampus (blue markers). A total of 25 data points are shown on each scatter plot (13 carriers, dark markers; 12 noncarriers, light markers; see Section ).

Article Snippet: To restrict our analysis to the PHCB, we extracted the PHCB mask [labeled “cingulum (hippocampus)”] from the Johns Hopkins University ICBM-DTI-81 white-matter tractography atlas using FSLView (for similar approach, see ).

Techniques: Activity Assay